Edkins, Adrienne L, Price, John T, Pockley, A Graham, Blatch, Gregory L. Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective. 2017.

Beckley, Samantha Joy, Hunter, Morgan C, Kituyi, Sarah N, Wingate, Ianthe, Chakraborty, Abantika, Schwarz, Kelly, Makhubu, Matodzi P, Rousseau, Robert P, Ruck, Duncan K, de la Mare, Jo-Anne, Blatch, Gregory L, Edkins, Adrienne L. STIP1/HOP regulates the actin cytoskeleton through interactions with actin and changes in actin-binding proteins cofilin and profilin:. 2020.

Thornton, Roxanne, Edkins, Adrienne L, Hutchinson, E F. Contributions of the pars lateralis, pars basilaris and femur to age estimations of the immature skeleton within a South African forensic setting:. 2020.

Chiwakata, M, de la Mare, Jo-Anne, Edkins, Adrienne L, Beukes, Denzil R. Georg Thieme Verlag KG; 2016. Sarqaquinoic acid and related synthetic naphthoquinones inhibit the function of Hsp90.

Edkins, Adrienne L, Boshoff, Aileen. Springer; 2014. General structural and functional features of molecular chaperones:.

Baindur-Hudson, Swati, Edkins, Adrienne L, Blatch, Gregory L. Springer; 2015. Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins.

Mattison, Stacey A, Blatch, Gregory L, Edkins, Adrienne L. HOP expression is regulated by p53 and RAS and characteristic of a cancer gene signature. 2018.

Dziwornu, Godwin A, Caira, Mino R, de la Mare, Jo-Anne, Edkins, Adrienne L, Bolton, John J, Beukes, Denzil R, Sunassee, Suthananda N. Isolation, characterization and antiproliferative activity of new metabolites from the South African endemic red algal species Laurencia alfredensis. 2017.

Tastan Bishop, Özlem, Edkins, Adrienne L, Blatch, Gregory L. Sequence and domain conservation of the coelacanth Hsp40 and Hsp90 chaperones suggests conservation of function. 2014.

Willmer, Tarryn, Contu, Lara, Blatch, Gregory L, Edkins, Adrienne L. Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines:. 2013.

Amemiya, Chris T, Alföldi, Jessica, Lee, Alison P, Fan, Shaohua, Philippe, Herve´, MacCallum, Iain, Braasch, Ingo, Manousaki, Tereza, Schneider, Igor, Rohner, Nicolas, Organ, Chris, Chalopin, Domitille, Smith, Jeramiah J, Robinson, Mark, Dorrington, Rosemary A, Gerdol, Marco, Aken, Bronwen, Biscotti, Maria Assunta, Barucca, Marco, Baurain, Denis, Berlin, Aaron, Blatch, Gregory L, Buonocore, Francesco, Burmester, Thorsten, Campbell, Michael S, Canapa, Adriana, Cannon, John P, Christoffels, Alan, De Moro, Gianluca, Edkins, Adrienne L, Fan, Lin, Fausto, Anna Maria, Feiner, Nathalie, Forconi, Mariko, Gamieldien, Junaid, Gnerre, Sante, Gnirke, Andreas, Goldstone, Jared V, Haerty, Wilfried, Hahn, Mark E, Hesse, Uljana, Hoffmann, Steve, Johnson, Jeremy, Karchner, Sibel I, Kuraku, Shigehiro, Lara, Marcia, Levin, Joshua Z, Litman, Gary W, Mauceli, Evan, Miyake, Tsutomu, Mueller, M Gail, Nelson, David R, Nitsche, Anne, Olmo, Ettore, Ota, Tatsuya, Pallavicini, Alberto, Panji, Sumir, Picone, Barbara, Ponting, Chris P, Prohaska, Sonja J, Przybylski, Dariusz, Ratan Saha, Nil, Ravi, Vydianathan, Ribeiro, Filipe J, Sauka-Spengler, Tatjana, Scapigliati, Giuseppe, Searle, Stephen M J, Sharpe, Ted, Simakov, Oleg, Stadler, Peter F, Stegeman, John J, Sumiyama, Kenta, Tabbaa, Diana, Tafer, Hakim, Turner-Maier, Jason, van Heusden, Peter, White, Simon, Williams, Louise, Yandell, Mark, Brinkmann, Henner, Volff, Jean-Nicolas, Tabin, Clifford J, Shubin, Neil, Schartl, Manfred, Jaffe, David B, Postlethwait, John H, Venkatesh, Byrappa, Di Palma, Frederica, Lander, Eric S, Meyer, Axel, Lindblad-Toh, Kerstin. The African coelacanth genome provides insights into tetrapod evolution:. 2013.

Edkins, Adrienne L, Blatch, Gregory L. Springer; 2012. Targeting conserved pathways as a strategy for novel drug development: disabling the cellular stress response:.

Edkins, Adrienne L, Blatch, Gregory L. Springer; 2014. The networking of chaperones by co-chaperones: control of cellular protein homeostasis.

de la Mare, Jo-Anne, Lawson, Jessica C, Chiwakata, Maynard T, Beukes, Denzil R, Blatch, Gregory L, Edkins, Adrienne L. Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro:. 2012.

de la Mare, Jo-Anne, Sterrenberg, Jason N, Sukhthankar, Mugdha G, Chiwakata, Maynard T, Beukes, Denzil R, Blatch, Gregory L, Edkins, Adrienne L. Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay:. 2013.

Mbaba, Mziyanda, Dingle, Laura M K, Swart, Tarryn, Cash, Devon, Laming, Dustin, de la Mare, Jo-Anne, Taylor, Dale, Hoppe, Heinrich C, Biot, Christophe, Edkins, Adrienne L, Khanye, Setshaba D. The in vitro antiplasmodial and antiproliferative activity of new ferrocene-based α-aminocresols targeting hemozoin inhibition and DNA interaction:. 2020.

Edkins, Adrienne L, Ludewig, M H, Blatch, Gregory L. A Trypanosoma cruzi heat shock protein 40 is able to stimulate the adenosine triphosphate hydrolysis activity of heat shock protein 70 and can substitute for a yeast heat shock protein 40. 2004.

Sterrenberg, Jason N, Edkins, Adrienne L, Blatch, Gregory L. Human DNAJ in cancer and stem cells:. 2011.

Mutsvunguma, Lorraine Z, Moetlhoa, Boitumelo, Edkins, Adrienne L, Luke, Garry A, Blatch, Gregory L, Knox, Caroline M. Theiler’s murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin:. 2011.

Lawson, Jessica C, Blatch, Gregory L, Edkins, Adrienne L. Cancer stem cells in breast cancer and metastasis:. 2009.

de la Mare, Jo-Anne, Jurgens, Tamarin, Edkins, Adrienne L. Extracellular Hsp90 and TGFP regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model. 2017.

Mandal, Gunjan, Biswas, Subir, Chowdhury, Sougata R, Chatterjee, Annesha, Purohit, Suman, Khamaru, Poulomi, Chakraborty, Sayan, Mandal, Palash K, Gupta, Arnab, de la Mare, Jo-Anne, Edkins, Adrienne L, Bhattacharyya, Arindam. Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression:. 2018.

Slater, Cindy, de la Mare, Jo-Anne, Edkins, Adrienne L. In vitro analysis of putative cancer stem cell populations and chemosensitivity in the SW480 and SW620 colon cancer metastasis model:. 2018.

Aliwaini, Saeb, Peres, Jade, Kröger, Wendy L, Blanckenberg, Angelique, de la Mare, Jo-Anne, Edkins, Adrienne L, Mapolie, Selwyn, Prince, Sharon. The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells:. 2015.

Gramni, Larusha, Vukea, Nyeleti, Chakraborty, Abir, Samson, William J, Dingle, Laura M K, Xulu, Bheki, de la Mare, Jo-Anne, Edkins, Adrienne L, Booysen, Irvin N. Anticancer evaluation of ruthenium (III) complexes with N-donor ligands tethered to coumarin or uracil moieties:. 2019.

Bromley, Candice L, Parker-Nance, Shirley, de la Mare, Jo-Anne, Edkins, Adrienne L, Beukes, Denzil R, Davies-Coleman, Michael T. Halogenated oxindole and indoles from the South African marine ascidian Distaplia skoogi:. 2013.

Ntsimango, Songeziwe, Gandidzanwa, Sendibitiyosi, Joseph, Sinelizwi V, Hosten, Eric C, Randall, Marvin, Edkins, Adrienne L, Khene, Samson M, Mashazi, Philani N, Nyokong, Tebello, Abrahams, Abubak’r, Tshentu, Zenixole R. Wiley Library Online; 2022. Reaction of Perrhenate with Phthalocyanine Derivatives in the Presence of Reducing Agents and Rhenium Oxide Nanoparticles in Biomedical Applications.

Mbaba, Mziyanda, de la Mare, Jo-Anne, Sterrenberg, Jason N, Kajewole, Deborah, Maharaj, Shantal, Edkins, Adrienne L, Isaacs, Michelle, Hoppe, Heinrich C, Khanye, Setshaba D. Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition.. .

de la Mare, Jo-Anne, Contu, Lara, Hunter, Morgan C, Moyo, Buhle, Sterrenberg, Jason N, Dhanani, Karim C H, Mutsvunguma, Lorraine Z, Edkins, Adrienne L. Breast cancer: current developments in molecular approaches to diagnosis and treatment. 2014.

Knott, Michael G, de la Mare, Jo-Anne, Edkins, Adrienne L, Zhang, Angel, Stillman, Martin J, Bolton, John J, Antunes, Edith M, Beukes, Denzil R. Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum. 2019.

Odeyemi, S W, de la Mare, Jo-Anne, Edkins, Adrienne L, Afolayan, A J. In vitro and in vivo toxicity assessment of biologically synthesized silver nanoparticles from Elaeodendron croceum:. 2019.

Maikoo, Sanam, Chakraborty, Abir, Vukea, Nyeleti, Dingle, Laura M K, Samson, William J, de la Mare, Jo-Anne, Edkins, Adrienne L, Booysen, Irvin N. Ruthenium complexes with mono-or bis-heterocyclic chelates: DNA/BSA binding, Antioxidant and Anticancer studies. 2020.

Mbaba, Mziyanda, Dingle, Laura M K, Cash, Devon, de la Mare, Jo-Anne, Laming, Dustin, Taylor, Dale, Hoppe, Heinrich C, Edkins, Adrienne L, Khanye, Setshaba D. Repurposing a polymer precursor: Synthesis and in vitro medicinal potential of ferrocenyl 1, 3-benzoxazine derivatives. 2020.

Boel, Natasha M-E, Hunter, Morgan C, Edkins, Adrienne L. LRP1 is required for novobiocin-mediated fibronectin turnover:. 2018.

Maikoo, Sanam, Dingle, Laura M K, Chakraborty, Abir, Xulu, Bheki, Edkins, Adrienne L, Booysen, Irvin N. Synthetic, characterization and cytotoxic studies of ruthenium complexes with Schiff bases encompassing biologically relevant moieties:. 2020.

Chakraborty, Abantika, Edkins, Adrienne L. Hop depletion reduces HSF1 levels and activity and coincides with reduced stress resilience:. 2020.

Chakraborty, Abir, Boel, Natasha M-E, Edkins, Adrienne L. HSP90 interacts with the fibronectin N-terminal domains and increases matrix formation:. 2020.

Lunga, Mayibongwe J, Chisango, Ruramai L, Weyers, Carli, Isaacs, Michelle, Taylor, Dale, Edkins, Adrienne L, Khanye, Setshaba D, Hoppe, Heinrich C, Veale, Clinton G L. Expanding the SAR of Nontoxic Antiplasmodial Indolyl-3-ethanone Ethers and Thioethers:. 2018.

Munedzimwe, Tatenda C, van Zyl, Rovyn L, Heslop, Donovan C, Edkins, Adrienne L, Beukes, Denzil R. Semi-synthesis and evaluation of sargahydroquinoic acid derivatives as potential antimalarial agents:. 2019.

Boel, Natasha M-E, Edkins, Adrienne L. Springer; 2018. Regulation of the extracellular matrix by heat shock proteins and molecular chaperones:.

Kirigin, Elisa, Ruck, Duncan Kyle, Jackson, Zoe, Murphy, James, McDonnell, Euan, Okpara, Michael O, Whitehouse, Adrian, Edkins, Adrienne L. Springer; 2020. Regulation of Kaposi’s Sarcoma-Associated Herpesvirus Biology by Host Molecular Chaperones:.

Kituyi, Sarah N, Edkins, Adrienne L. Hop/STIP1 depletion alters nuclear structure via depletion of nuclear structural protein emerin:. 2018.

Swart, Tarryn, Khan, Farrah D, Ntlantsana, Apelele, Laming, Dustin, Veale, Clinton G L, Przyborski, Jude M, Edkins, Adrienne L, Hoppe, Heinrich C. Detection of the in vitro modulation of Plasmodium falciparum Arf1 by Sec7 and ArfGAP domains using a colorimetric plate-based assay:. 2020.

Mbaba, Mziyanda, Mabhula, Amanda N, Boel, Natasha, Edkins, Adrienne L, Isaacs, Michelle, Hoppe, Heinrich C, Khanye, Setshaba D. Ferrocenyl and organic novobiocin derivatives: synthesis and their in vitro biological activity. 2017.

Dhanani, Karim C H, Samson, William J, Edkins, Adrienne L. Fibronectin is a stress responsive gene regulated by HSF1 in response to geldanamycin. 2017.

Lunga, Mayibongwe J, Chisango, Ruramai Lissa, Weyers, Carli, Isaacs, Michelle, Taylor, Dale, Edkins, Adrienne L, Khanye, Setshaba D, Hoppe, Heinrich C, Veale, Clinton G L. Expanding the SAR of Nontoxic Antiplasmodial Indolyl-3-ethanone Ethers and Thioethers.. .

Veale, Clinton G L, Chen, Weiyang, Chaudhary, Sushil, Kituyi, Sarah N, Isaacs, Michelle, Hoppe, Heinrich C, Edkins, Adrienne L, Combrinck, Sandra, Mehari, Bewketu, Viljoen, Alvaro. NMR structural elucidation of channaine, an unusual alkaloid from Sceletium tortuosum:. 2018.

Edkins, Adrienne L. Springer International Publishing Switzerland; 2016. Hsp90 co-chaperones as drug targets in cancer: current perspectives.

Faridoon, H, Edkins, Adrienne L, Isaacs, Michelle, Mnkandhla, Dumisani, Hoppe, Heinrich C, Kaye, Perry T. Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors. 2016.

Pesce, Eva-Rachele, Blatch, Gregory L, Edkins, Adrienne L. Springer International Publishing Switzerland; 2016. Hsp40 Co-chaperones as drug targets: towards the development of specific inhibitors.

McAlpine, Shelli R, Edkins, Adrienne L. Springer International Publishing Switzerland; 2016. Heat shock protein inhibitors: success stories.

Veale, Clinton G L, Edkins, Adrienne L, de la Mare, Jo-Anne, de Kock, Carmen, Smith, Peter J, Khanye, Setshaba D. Facile synthesis and biological evaluation of assorted indolyl-3-amides and esters from a single, stable carbonyl nitrile intermediate. 2015.

Kramer, Adam H, Edkins, Adrienne L, Hoppe, Heinrich C, Prinsloo, Earl. Dynamic mitochondrial localisation of STAT3 in the cellular adipogenesis model 3T3-L1:. 2015.

Cooper, Leanne C, Prinsloo, Earl, Edkins, Adrienne L, Blatch, Gregory L. Hsp90α/β associates with the GSK3β/axin1/phospho-β-catenin complex in the human MCF-7 epithelial breast cancer model:. 2011.

Prinsloo, Earl, Kramer, Adam H, Edkins, Adrienne L, Blatch, Gregory L. STAT3 interacts directly with Hsp90:. 2012.

Kramer, Adam H, Joos-Vandewalle, Julia, Edkins, Adrienne L, Frost, Carminita L, Prinsloo, Earl. Real-time monitoring of 3T3-L1 preadipocyte differentiation using a commercially available electric cell-substrate impedance sensor system:. 2014.

Hunter, Morgan C, O’Hagan, Kyle L, Kenyon, Amy, Dhanani, Karim C H, Prinsloo, Earl, Edkins, Adrienne L. Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells:. 2014.

Acharya, Mridu, Edkins, Adrienne L, Ozanne, B, Cushley, W. SDF-1 and PDGF enhance αvβ5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines:. 2009.

Edkins, Adrienne L. Springer; 2015. CHIP: a co-chaperone for degradation by the proteasome.

Jauka, Tembisa, Mutsvunguma, Lorraine Z, Boshoff, Aileen, Edkins, Adrienne L, Knox, Caroline M. Localisation of Theiler's murine encephalomyelitis virus protein 2C to the golgi apparatus using antibodies generated against a peptide region:. 2010.

Adeyemi, Oluyomi, Edkins, Adrienne L, Whiteley, Christopher. Metal nanoparticles caused death of metastatic MDA-MB-231 breast cancer cells:. 2013.

Edkins, Adrienne L, Borland, Gillian, Acharya, Mridu, Cogdell, Richard, Ozanne, Bradford W, Cushley, William. Differential regulation of monocyte cytokine release by αV and β2 integrins that bind CD23:. 2012.

Hunter, Morgan C, O’Hagan, Kyle L, Kenyon, Amy, Dhanani, Karim C H, Prinsloo, Earl, Edkins, Adrienne L. PLOSOne; 2014. Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells.

Kramer, Adam H, Joos-Vandewalle, Julia, Edkins, Adrienne L, Frost, Carminita L, Prinsloo, Earl. Elsevier; 2014. Real-time monitoring of 3T3-L1 preadipocyte differentiation using a commercially available electric cell-substrate impedance sensor system.

Olsen, Elisabeth, De Cerf, Christopher, Dziwornu, Godwin A, Puccinelli, Eleonora, Parker-Nance, Shirley, Ansorge, Isabelle J, Samaai, Toufiek, Dingle, Laura M K, Edkins, Adrienne L, Sunassee, Suthananda N. South African Journal of Science; 2016. Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean.

Weyers, Carli, Dingle, Laura M K, Wilhelmi, Brendan S, Edkins, Adrienne L, Veale, Clinton G L. Use of a non-hepatic cell line highlights limitations associated with cell-based assessment of metabolically induced toxicity:. 2020.

Sunassee, Suthananda N, Veale, Clinton G L, Shunmoogam-Gounden, Nelusha, Osoniyi, Omalaja, Hendricks, Denver T, Caira, Mino R, De la Mare, Jo-Anne, Edkins, Adrienne L, Pinto, Antônio V, Da Silva Junior, Eufrânio N, Davies-Coleman, Michael T. Cytotoxicity of lapachol, β-lapachone and related synthetic 1, 4-naphthoquinones against oesophageal cancer cells:. 2013.